Quinidine

From Ask Dr Wiki

Contents 1 Dosage forms 2 Side Effects 3 Drug Interactions 4 ECG Effects 5 Considerations

Dosage forms

• Sulfate 80 % base
• Gluconate 62% base
• Polygalacturonate 60 % base
• Therapeutic range: 1.5 - 5 mcg/ml

Side Effects

• Torsades de Pointes
• GI Side Effects
• Hypotension
• Alpha 1-blockade
• Thrombocytopenia immune mediated
• SLE

Drug Interactions

• Digoxin
• Warfarin
• Amiodarone
• Quinidine inhibits CYP2D6

• Codeine
• Flecainide
• Mexiletine
• Propafenone
• Certain b-blockers

ECG Effects

• Prolongs QT interval
• Prolongs QRS
• ± PR interval

Considerations

• Quinidine Increases AV-nodal conduction
• Monitor QT interval daily while initiating therapy
• Decrease dose in patients with CHF or liver disease
• Monitor LFTs periodically
• Monitor for drug interactions