Procainamide Administration for Interventricular Conduction Delay

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  • Intracardiac conduction was assessed by recording of the His bundle electrocardiogram and atrial pacing techniques, before and 20 minutes after intravenous administration of procainamide, in a dose of up to 10 mg/kg.
  • Before procainamide administration, seven of the 12 patients had a prolonged H-V interval (greater than 55 ms). Procainamide administration lengthened the H-V interval in all 12 patients by 5--40 ms.
  • In five patients, procainamide induced second or third degree AV block below the level of the bundle of His. It was concluded that the administration of procainamide may be a useful provocative test of distal conduction in patients with possible intermittent AV block.

References

Intermittent atrioventricular block: procainamide administration as a provocative test. AU Tonkin AM; Heddle WF; Tornos P; SO Aust N Z J Med 1978 Dec;8(6):594-602.

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