Discriminant function

From Ask Dr Wiki

Discriminant function (also called modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott^[1] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

<math>\left [{4}.{6}\times\ prothombin\ time\ -\ control\ value\ (seconds)\right ]\ +\ serum\ bilirubin\ (mg/dl)\,</math>

Prospective studies have shown that, it is useful in predicting short term prognosis especially mortality within 30 days^[2]. A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%^[3].

See also

• Model for End-Stage Liver Disease
• Child-Pugh score

Reference list

1. ↑ {{#if:Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI |{{#if: |[[{{{authorlink}}}|{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI }}]] |{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI }} }} }}{{#if:Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI |{{#if: | ; {{{coauthors}}} }} }}{{#if: | ({{{date}}}) |{{#if:1978 |{{#if: | ({{{month}}} 1978) | (1978) }} }} }}{{#if:Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI | . }}{{#if:Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI1978 | }}{{#ifeq: | no | | {{#if: |“|"}} }}{{#if: |[{{{url}}} Corticosteroid therapy of alcoholic hepatitis] |Corticosteroid therapy of alcoholic hepatitis }}{{#ifeq: | no | | {{#if:|”|"}} }}{{#if: | (in {{{language}}}) }}{{#if: | ({{{format}}}) }}{{#if:Gastroenterology |. Gastroenterology }}{{#if:75 | 75 }}{{#if:2 | (2) }}{{#if:193-9 |: 193-9 }}{{#if: |. {{#if: |{{{location}}}: }}{{{publisher}}} }}{{#if: |. doi:[1] }}{{#if: |. ISSN {{{issn}}} }}{{#if:352788 |. PMID 352788 }}{{#if: |. Bibcode: {{{bibcode}}} }}{{#if: |. OCLC {{{oclc}}} }}{{#if: |. {{{id}}} }}{{#if: |. Retrieved on [[{{{accessdate}}}]]{{#if: | , [[{{{accessyear}}}]] }} }}{{#if: | Retrieved on {{{accessmonthday}}}, {{{accessyear}}} }}{{#if: | Retrieved on {{{accessdaymonth}}} {{{accessyear}}} }}{{#if: |. [{{{laysummary}}} Lay summary]{{#if: | – {{{laysource}}}}} }}{{#if: | ([[{{{laydate}}}]]) }}.{{#if: | “{{{quote}}}” }}
2. ↑ {{#if:Sheth M, Riggs M, Patel T |{{#if: |[[{{{authorlink}}}|{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Sheth M, Riggs M, Patel T }}]] |{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Sheth M, Riggs M, Patel T }} }} }}{{#if:Sheth M, Riggs M, Patel T |{{#if: | ; {{{coauthors}}} }} }}{{#if: | ({{{date}}}) |{{#if:2002 |{{#if: | ({{{month}}} 2002) | (2002) }} }} }}{{#if:Sheth M, Riggs M, Patel T | . }}{{#if:Sheth M, Riggs M, Patel T2002 | }}{{#ifeq: | no | | {{#if: |“|"}} }}{{#if: |[{{{url}}} Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis] |Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis }}{{#ifeq: | no | | {{#if:|”|"}} }}{{#if: | (in {{{language}}}) }}{{#if: | ({{{format}}}) }}{{#if:BMC gastroenterology |. BMC gastroenterology }}{{#if:2 | 2 }}{{#if: | () }}{{#if:2 |: 2 }}{{#if: |. {{#if: |{{{location}}}: }}{{{publisher}}} }}{{#if: |. doi:[2] }}{{#if: |. ISSN {{{issn}}} }}{{#if:11835693 |. PMID 11835693 }}{{#if: |. Bibcode: {{{bibcode}}} }}{{#if: |. OCLC {{{oclc}}} }}{{#if: |. {{{id}}} }}{{#if: |. Retrieved on [[{{{accessdate}}}]]{{#if: | , [[{{{accessyear}}}]] }} }}{{#if: | Retrieved on {{{accessmonthday}}}, {{{accessyear}}} }}{{#if: | Retrieved on {{{accessdaymonth}}} {{{accessyear}}} }}{{#if: |. [{{{laysummary}}} Lay summary]{{#if: | – {{{laysource}}}}} }}{{#if: | ([[{{{laydate}}}]]) }}.{{#if: | “{{{quote}}}” }}
3. ↑ {{#if:Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O |{{#if: |[[{{{authorlink}}}|{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O }}]] |{{#if: |{{{last}}}{{#if: |, {{{first}}} }} |Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O }} }} }}{{#if:Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O |{{#if: | ; {{{coauthors}}} }} }}{{#if: | ({{{date}}}) |{{#if:2000 |{{#if: | ({{{month}}} 2000) | (2000) }} }} }}{{#if:Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O | . }}{{#if:Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O2000 | }}{{#ifeq: | no | | {{#if: |“|"}} }}{{#if: |[{{{url}}} Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial] |Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial }}{{#ifeq: | no | | {{#if:|”|"}} }}{{#if: | (in {{{language}}}) }}{{#if: | ({{{format}}}) }}{{#if:Gastroenterology |. Gastroenterology }}{{#if:119 | 119 }}{{#if:6 | (6) }}{{#if:1637-48 |: 1637-48 }}{{#if: |. {{#if: |{{{location}}}: }}{{{publisher}}} }}{{#if: |. doi:[3] }}{{#if: |. ISSN {{{issn}}} }}{{#if:11113085 |. PMID 11113085 }}{{#if: |. Bibcode: {{{bibcode}}} }}{{#if: |. OCLC {{{oclc}}} }}{{#if: |. {{{id}}} }}{{#if: |. Retrieved on [[{{{accessdate}}}]]{{#if: | , [[{{{accessyear}}}]] }} }}{{#if: | Retrieved on {{{accessmonthday}}}, {{{accessyear}}} }}{{#if: | Retrieved on {{{accessdaymonth}}} {{{accessyear}}} }}{{#if: |. [{{{laysummary}}} Lay summary]{{#if: | – {{{laysource}}}}} }}{{#if: | ([[{{{laydate}}}]]) }}.{{#if: | “{{{quote}}}” }}

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