Thyrotropin

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Synonyms: TSH, TSH 1, Thyreotropin, thyroid stimulating hormone

German: Thyreotropin

Thyrotropin is a glycopeptide hormone that is secreted by the anterior pituitary lobe. It stimulates formation of thyroid hormones in the thyroid gland. Conversely, in the context of a feedback control TSH secretion in the pituitary is inhibited by thyroid hormones (thyrotropic feedback control).

Physiology

The following factors influence secretion of TSH:

Stimulating factors

• TRH
• Neurotensin
• Norepinephrine
• Leptin
• Vasopressin (ADH, presumably)

Inhibiting factors

• Thyroxine (T4) and Triiodothyronine (T3)
• Somatostatin
• Dopamin
• Glucocorticoids
• TSH
• Thyrostimulin (TSH 2)
• Cytokines (presumably)