Thyrotropin

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Synonyms: TSH, TSH 1, Thyreotropin, thyroid stimulating hormone

German: Thyreotropin

Thyrotropin is a glycopeptide hormone that is secreted by the anterior pituitary lobe. It stimulates formation of thyroid hormones in the thyroid gland. Conversely, in the context of a feedback control TSH secretion in the pituitary is inhibited by thyroid hormones (thyrotropic feedback control).^[1]

Contents 1 Physiology 1.1 Stimulating factors 1.2 Inhibiting factors 2 References

Physiology

The following factors influence secretion of TSH:

Stimulating factors

• TRH
• Neurotensin
• Norepinephrine
• Leptin
• Vasopressin (ADH, presumably)

Inhibiting factors

• Thyroxine (T4) and Triiodothyronine (T3)
• Somatostatin
• Dopamin
• Glucocorticoids
• TSH
• Thyrostimulin (TSH 2)
• Cytokines (presumably)

References

1. ↑ Dietrich JW, Landgrafe, G, Fotiadou, EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. doi:10.1155/2012/351864