Drug Eluting Stents

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Drug Eluting Stent

A drug eluting stent (DES) is a normal metal stent which has been covered or coated with a pharmacologic agent designed to interfere with thrombosis or restenosis. Restenosis leading to revascularization is one of the main limiting factors driving the adverse events with angioplasy. With the advent of stents coated with agents designed limit restenosis and trials showing their efficacy in decreasing this end point, the world market for these devices doubled. Recent concerns with the occurence of late stent thombosis led to a special FDA advisiory panel to examine their use. This risk seems to be related to the sudden stopage of dual antiplatelet therapy with aspirin and clopidogrel (Plavix™)

Currently in the US, there are two DES platforms currently in use. The Cordis Cypher™ stent is a sirolimus-eluting stent and the Boston Scientific Taxus™ stent is a paclitaxel-eluting stent.

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